Despite several prior training revealing an association anywhere between blood pressure level and you may the brand new urinary Na + /K + proportion you will find some restrictions to be sensed
At present there is conflicting evidence regarding the potential blood pressure lowering effects of a reduction in urinary Na + /K + excretion. The TAIM randomized control trial in hypertensive participants on a pharmacological intervention reported no significant difference in DBP between the control diet group and a low Na + /high K + diet group during a six month period . A multicenter study by Suppa et al. conducted in hypertensive participants reported a significant reduction in SBP following 4 weeks of modified low sodium high potassium salt intake compared to participants receiving a normal salt intake , yet all participants were receiving a beta blocker, which is not standard first line treatment for hypertension . In addition, a cross-sectional study, the Dallas heart study, which reported an increase in SBP for an increase in the urinary Na + /K + ratio is limited by the modest correlation the use of single morning urine sample . The PURE study reported a strong linear association between estimated Na + /K + ratio and SBP, that was maintained after covariate adjustment, with the greatest SBP observed with the highest estimated K + and lowest estimated K + excretion . Although we observed that a daily K + excretion of <1 g/day is associated with elevated SBP we observed no association between the urinary Na + /K + excretion ratio and SBP at screening or following DASH-dietary intervention in SS or SR participants. In conjunction with the study by Zanetti et al. , our data suggest high Na + and low K + excretion may increase the likelihood of having increased SBP. However, the lack of association between urinary Na + /K + ratio and SBP in our data do not support a urinary Na + /K + molar excretion ratio of 1:1 as a mechanism to lower blood pressure [16, 17].
The current analysis has several strengths: (1) The brand new Dashboard -Salt demo is actually a thoroughly managed eating studies and you may compliance was continuously monitored, (2) The new crossover construction to possess Na + input https://datingranking.net/pl/hookupdate-recenzja/ acceptance participant’s so you can act as her control and you may reduced inter-person variability, (3) 24-h ambulatory blood pressure level tracks were removed, (4) absence of the confounding results of antihypertensive mediations, and you will (5) 24-h urine attempt collection. The big limit of your own establish study ‘s the seemingly modest test dimensions that may provides diminished our very own mathematical capability to select modest negative effects of urinary Na + , K + , and Na + :K + proportion towards the SBP. As we don’t to see an imbalance from inside the standard functions, recurring confounding in our analysis is achievable.
Next, the brand new INTERSALT study, and this reported an optimistic organization between your urinary Na + /K + ratio and you can blood circulation pressure stated a loss in mathematical significance of new relationship inside 44 of the 52 facilities just after modifications to have covariates including decades, sex and you will Body mass index [thirty two, 33]
In conclusion the modern studies of the Dash–Sodium Trial indicates that losing weight K + supplementation isn’t regarding the straight down SBP hence the new decrease in SBP observed adopting the Dash weightloss intervention occurred independently away from an effective reduced total of the fresh urinary Na + /K + removal proportion despite brand new sodium susceptibility of blood pressure level. Our very own research do not hold the place regarding a-1:1 molar excretion proportion off Na + /K + since blood pressure minimizing means during the All of us Dark colored and you may non-African Us americans and you may hold the DRI recommendation to not ever suggest each and every day K + consumption recommendations. Given the limits of most recent study therefore the ongoing controversy regarding your role out-of dieting K + into blood pressure level future very carefully controlled research is necessary to clarify the possibility effect out-of fat loss K + and you can urinary Na + /K + removal ratio on blood pressure levels in both hypertensive and you can normotensive SS and SR professionals.